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There are currently over 117,000 articles and research papers written on the benefits of adequate levels of nitric oxide since the Nobel Prize was awarded in 1998. The scientific community is encouraged by the expanding understanding of how this simple molecule can significantly reduce the risk factors of cardiovascular disease, stroke, diabetes and a host of other disorders. While the significant benefit of this science was economically detoured into the male enhancement drug industry, the holistic benefits of nitric oxide are now available to the consumer as never before.

Food and Supplementation

Though high risk factors such as diabetes, obesity, atherosclerosis and high cholesterol interfere with the endothelial production of nitric oxide, the parallel synthesis pathway utilizing nitrates and nitrites from nitrogen-based food nutrients can provide the necessary nitric oxide.

This combined with supplementation of powerful antioxidants can provide the body with the net nitric oxide effect it needs to provide optimal cardiovascular and immune wellness. Water soluble antioxidants such as those found in fruits and vegetables mitigate the scavenging effect on nitric oxide by powerful free radicals such as superoxide and peroxynitrite.

Fat soluble antioxidants, especially the desmethyl tocotrienol fractions of Vitamin E, assist significantly in reducing the effects of oxidative stress and allow for a more enhanced cardio and immuno-protective effect of increased nitric oxide production.4,5

For many years virtually all of the research surrounding the potential benefits of Vitamin E were centered around the tocopherol isomers of Vitamin E, primarily the alpha isoform. More recent studies have re-visited these studies with Vitamin E stripped of tocopherol finding that it is indeed the tocotrienol fractions, primarily the delta and gamma forms, that provide the greatest health benefits. These tocotrienol fractions, with greatly increased bio-action and benefit due to increased numbers of double bonds, are now understood to be associated with decreasing the viability of cancer cells, increased immune function, cardio-protective benefits and others.6,7

Therefore the best approach is one that utilized the best of both worlds. Specificity is required in the delivery of the adjustment and specificity is also required in the form of targeted nutrition to enhance circulation, cellular repair and optimal function at the most basic cellular level.

The IVD and supporting structures must be able to receive the adjustment and heal with integrity, both functional and at a cellular level.

My earlier attempts at a 'shotgun' approach to nutrition is not only time intensive but inherently allopathic. It makes more sense to me to provide my patients with an understanding of how nutrition supports integrity of tissue and ligament.

Not a Cure-All

The science of nitric oxide is not a cure-all. Whole food nutrition, daily exercise, regular chiropractic care, sensible advice in daily work-place and personal ergonomics are the keys to an effective and sustainable result.

However now that I understand the impact of nitric oxide science, antioxidant protection, and EFA supplementation; I see the value in expanding the service and value of what I offer to my patients.

Please take the time to do a little research in regards to the essential nutrients. While of course the best delivery method would be whole foods, the reality of modern day society combined with the severe depletion of nutrients from foods provided by the present day food industry, wise and thoughtful supplementation is the key to optimal results in practice and optimal wellness for those we serve.


  1. Anderson, R, Chinn, P. What are the health benefits of supplementing with the amino acid L-Arginine. The American Chiropractor 2011;46-9.
  2. Davies, SA, et al. Neuropeptide stimulation of the nitric oxide signaling pathway in Drosophila melanogaster Malpighian tubules. Am J Physiol 1997;273:R823
  3. Yin, H, et al. Nitric oxide mediates cardiac protection of tissue kallikrein by reducing inflammation and ventricular remodeling after myocardial ischemia/reperfusion. Life Sci 2008; 82:156
  4. Serlrinova, E et al. Free radical recycling and intramembrane notrility in the antioxidant properties of alpha-tocopherol and
    alpha-tocotrienol. Free Rad boil Med, 1991;10:263-275.
  5. Yoshida, Y et al. Comparative study on the action of tocopherols and tocotrienols as antioxidant. Chem Phys Lip, 2003; 123:63-75.
  6. Miyamoto, K et al. Very-high-dose alpha-tocopherol supplementation increases blood pressure and causes possible adverse central nervous system effects in stroke-prone spontaneously hypertensive rats. J Neurosci Res, 2009; 87(2):556-66.
  7. Aggarwal BB, et al. Tocotrienols, the Vitamin E of the 21st century; its potential against cancer and other chronic diseases. Biochem Pharmacol. 2010 Dec 1; 80(11):1613-31.

Dr. Perry Chinn is a 1986 Life graduate (Marietta) and has been practicing in the Seattle area for 25 years. He is Sec./Treas. and diplomate of the Gonstead Clinical Studies Society. He is the co-creator of the nutritional cardiovascular formula Acctrix, co-founder of Unisal Wellness Technologies, distributor and contributing author for His web site is and he can be reached at .

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